By: Jim Williams – Capital Sports Network – Senior Columnist
The NFC West heats up as the Los Angeles Rams (6-2) travel north to face the San Francisco 49ers (6-3) in a Week 10 clash that could reshape the division race. The Rams are riding a three-game win streak, while the 49ers are fresh off a 34-24 win over the Giants.
Key players to watch:
- Rams: QB Matthew Stafford (281 yards, 4 TDs vs Saints), WR Puka Nacua (league leader in receiving yards), RB Kyren Williams
- 49ers: QB Mac Jones (235 yards, 2 TDs vs Giants), RB Christian McCaffrey (106 rushing yards, 1 TD), WR Brandon Aiyuk
Broadcast Information
- Kickoff: Sunday, Nov. 9, 2025 at 4:25 PM ET
- TV: FOX
- Streaming: NFL+ and FOX Sports app
- Radio (Rams): ESPN LA 710 AM
- Radio (49ers): KNBR 680 AM / 104.5 FM
506Sports confirms this is the featured late afternoon game in most national markets.
Final Thoughts: What a Win Means
- For the Rams: A win would extend their streak to four and solidify their lead in the NFC West. Stafford’s MVP campaign would gain steam, and Sean McVay’s squad would avenge their Week 5 overtime loss to San Francisco.
- For the 49ers: Victory would give Kyle Shanahan a season sweep of the Rams and keep San Francisco in contention for a top playoff seed. With Brock Purdy still sidelined, Mac Jones has a chance to prove he’s more than a stopgap.
This rivalry has playoff implications and emotional weight. Expect intensity, precision, and a battle worthy of primetime.
